Chitosan is one of the most widely used natural hydrophilic polymers. Its nontoxic, biocompatible, antibacterial and biodegradable properties have led to significant research towards drug delivery applications. The primary amino groups in chitosan act as the reactive site for a variety of new group attachment to generate different physical and chemical derivatives using mild reaction conditions. Their amino groups are also responsible for various properties of chitosan such as cationic nature, controlled drug release, muco-adhesion, permeation enhancement, etc. Different formulations of chitosan materials as microspheres, tablets, nanoparticles, nanofibers have been explored for drug delivery applications